Johanna "Jo" Mitchell is a 17-year-old tomboy, who lives with her father, who works as a race car driver for NASCAR. The first day of school, she explains that she wants to avoid high school drama, and already knows some of the mean-spirited cliques to expect when going to North Shore High School. Then she introduces the school's most popular clique, "The Plastics" (from the first Mean Girls movie). This time "The Plastics" consist of Amanda "Mandi" Weatherly, a rich snobish girl who lives down the street from Jo; Chastity Meyer, a seemingly slow-witted blond with a raging libido who is known to randomly hook up with guys (even those less popular than she); and Hope Plotkin, a snobbish hypochondriac who seems to suck up to Mandi the most.
(These "Plastics" despite the original members who wore sexier clothes and dressed "sluttier". The new "Plastics" are more preppy and wear more floral outfits).
Jo is set to pretty much avoid The Plastics and she then meets Abigail "Abby" Hanover, a tortured artist who is actually neighbors with Mandi (they have been competing since they were little kids because Abby is a lot richer than Mandi's family). Abby tells Jo she is apart of the very small welcoming committee and then a teacher trips, accidentally throwing his shake on Abby. Jo at this point feels very sorry for Abby.